Yes, there can be interactions between Advil (ibuprofen) and certain antidepressants. According to the National Center for Biotechnology Information (NCBI), ibuprofen, the active ingredient in Advil, can interact with antidepressants known as selective serotonin reuptake inhibitors (SSRIs) [2].

One such interaction is called serotonin syndrome, which occurs when the body has too much serotonin, a neurotransmitter in the brain [2]. This can happen when ibuprofen is taken with SSRIs like Zoloft (sertraline) [3]. Symptoms of serotonin syndrome can include agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, diarrhea, fever, shivering, sweating, and seizures [2].

Another potential interaction is that ibuprofen can increase the risk of stomach ulcers and bleeding when taken with SSRIs [2].

It's important to note that not all antidepressants will interact with Advil in this way. For example, tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs) have different types of interactions with ibuprofen [2].

Therefore, it's always best to consult with a healthcare provider or pharmacist before taking any new medications, including over-the-counter drugs like Advil, especially if you are currently taking antidepressants or other prescription medications [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884264/
[3] https://www.singlecare.com/blog/ibuprofen-and-zoloft/