Lipitor is a medication used to lower cholesterol levels in the blood, while antidepressants are used to treat depression and other mental health conditions. According to the sources provided, there is a potential for adverse effects when combining Lipitor and certain antidepressants.

One study published in the Journal of the American Medical Association found that the combination of Lipitor and certain antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs), can increase the risk of developing a condition called rhabdomyolysis [2]. Rhabdomyolysis is a serious condition that can lead to muscle breakdown, kidney damage, and even death.

Another article from the American Academy of Family Physicians states that combining Lipitor with certain antidepressants, including SSRIs and tricyclic antidepressants (TCAs), can increase the risk of side effects such as dizziness, fatigue, and muscle pain [3]. The article suggests that patients who are taking Lipitor and antidepressants should be closely monitored for any signs of adverse effects.

However, it is important to note that not all antidepressants have been found to interact negatively with Lipitor. A study published in the journal Clinical Pharmacology and Therapeutics found that the combination of Lipitor and the antidepressant bupropion did not result in any significant drug interactions [1].

In conclusion, while some antidepressants can potentially interact negatively with Lipitor, not all antidepressants have been found to do so. Patients who are taking Lipitor and antidepressants should be closely monitored for any signs of adverse effects, and should consult with their healthcare provider if they have any concerns.

Sources:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812382/
[2] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[3] https://www.aafp.org/pubs/afp/issues/2007/0801/p391.html