Antihistamines and Lipitor (atorvastatin) are both commonly used medications, but there is limited information available on whether antihistamines can worsen Lipitor side effects.

Lipitor is a statin medication used to lower cholesterol levels and reduce the risk of heart disease [1]. Common side effects of Lipitor include headache, muscle and joint pain, and digestive issues such as diarrhea, constipation, and gas [1].

Antihistamines are medications used to treat allergies and allergic reactions [2]. They work by blocking the action of histamine, a substance in the body that causes allergic symptoms [2]. Common side effects of antihistamines include dizziness, drowsiness, and dry mouth [2].

There is no specific evidence or warning from the drug manufacturer or the Food and Drug Administration (FDA) indicating that antihistamines can worsen Lipitor side effects [1][3]. However, it is always important to consult with a healthcare provider or pharmacist before taking any new medications, especially if you are currently taking other medications or have existing health conditions.

In rare cases, antihistamines can interact with other medications and cause serious side effects [2]. It is important to inform your healthcare provider of all medications you are taking, including over-the-counter medications and supplements, to avoid potential drug interactions [2].

In conclusion, while there is no specific evidence indicating that antihistamines can worsen Lipitor side effects, it is always important to consult with a healthcare provider before taking any new medications.

Sources:

[1] Lipitor (atorvastatin) [Drug Monograph]. (2018). In DailyMed [Internet]. Bethesda, MD: National Library of Medicine. Available from: <https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6d3e1e2e-9f34-4e11-b752-f42f98f5b0b5&type=display>

[2] Antihistamines. (2021). In Mayo Clinic [Internet]. Rochester, MN: Mayo Foundation for Medical Education and Research. Available from: <https://www.mayoclinic.org/diseases-conditions/hay-fever/in-depth/antihistamines/art-20044210>

[3] FDA Label for Lipitor (atorvastatin calcium) tablets, for oral use. (2016). In DailyMed [Internet]. Bethesda, MD: National Library of Medicine. Available from: <https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6d3e1e2e-9f34-4e11-b752-f42f98f5b0b5&type=display>

Additional source:

DrugPatentWatch. (2021). Atorvastatin Calcium. In DrugPatentWatch [Internet]. Washington, DC: DrugPatentWatch. Available from: <https://www.drugpatentwatch.com/drugs/atorvastatin-calcium>