Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels and reduce the risk of heart disease [1]. According to the FDA, Lipitor is not known to have any significant drug interactions with antidepressants [2]. However, a study published in the US National Library of Medicine found that certain antidepressants, specifically fluoxetine and fluvoxamine, can increase the concentration of Lipitor in the blood, potentially leading to adverse effects [3].

The study suggests that patients taking Lipitor and these specific antidepressants should have their Lipitor dosage adjusted to prevent potential side effects. However, it is important to note that this study only looked at two specific antidepressants and further research may be needed to determine if other antidepressants have similar effects on Lipitor.

In conclusion, while Lipitor is not known to have significant drug interactions with antidepressants according to the FDA, certain antidepressants may increase the concentration of Lipitor in the blood. Patients taking Lipitor and these specific antidepressants should have their Lipitor dosage adjusted to prevent potential side effects. It is important to consult with a healthcare professional before making any changes to medication dosages.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.fda.gov/media/155050/download
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/