Vascepa (icosapent ethyl) is a prescription medication that contains omega-3 fatty acids and is used to lower triglyceride levels in adults with severe hypertriglyceridemia [1]. The medication has not been found to have any direct effect on antidepressant efficacy. However, the use of omega-3 fatty acids has been studied as a potential adjunctive therapy for depression.

A study published in the Journal of Clinical Psychiatry found that omega-3 fatty acid supplementation can be an effective adjunctive therapy for depression, especially in patients who do not respond to antidepressant medications alone [2]. However, this study did not specifically examine the effects of Vascepa on antidepressant efficacy.

According to Drugs.com, Vascepa should be used with caution in patients who are taking medications that affect platelet function or anticoagulants, as it may increase the risk of bleeding [3]. It is important for patients to discuss all medications they are taking with their healthcare provider to ensure safe and effective treatment.

In conclusion, Vascepa is a medication used to lower triglyceride levels and has not been found to have any direct effect on antidepressant efficacy. However, omega-3 fatty acids, which are present in Vascepa, have been studied as a potential adjunctive therapy for depression. Patients should discuss all medications they are taking with their healthcare provider to ensure safe and effective treatment.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628733/
[3] https://www.drugs.com/tips/vascepa-patient-tips