Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. According to the sources provided, taking Lipitor with fatty meals may reduce its effectiveness. The absorption of atorvastatin is decreased when taken with food, especially high-fat meals, which can decrease the drug's bioavailability [1][2]. It is recommended to take Lipitor at the same time each day, either with or without food, but to avoid consuming grapefruit or grapefruit juice as it can increase the risk of side effects [2]. Patients should also inform their healthcare provider of any changes in their diet or medication regimen to ensure optimal treatment outcomes [3].

In summary, Lipitor's effectiveness may be reduced when taken with fatty meals, as it can decrease the drug's absorption. Patients should take Lipitor at the same time each day, either with or without food, and avoid consuming grapefruit or grapefruit juice to reduce the risk of side effects. It is important to inform healthcare providers of any changes in diet or medication regimen to ensure optimal treatment outcomes.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://patient.info/medicine/atorvastatin-tablets-lipitor
[3] https://www.uspharmacist.com/article/fooddrug-interactions