What side effects are most commonly reported with Mavyret?
Mavyret (glecaprevir/pibrentasvir) commonly causes mild to moderate side effects such as fatigue and headache. Some people also report nausea and diarrhea. [1][2]
What side effects are more serious, and when should I get medical help?
Serious reactions are uncommon, but you should seek urgent medical care if you develop signs of a severe allergic reaction (such as trouble breathing, facial or throat swelling, or widespread hives). Also contact a clinician promptly if you notice symptoms that could suggest liver problems, including worsening jaundice (yellowing of the skin/eyes), dark urine, severe abdominal pain, or persistent vomiting. [1][2]
Do side effects differ depending on why you’re taking Mavyret?
Side effects are generally similar across major patient groups, but tolerability can vary. The biggest practical differences usually come from other health conditions (especially advanced liver disease) and other medications taken at the same time, rather than the hepatitis C genotype alone. [1][2]
Can Mavyret cause liver-related side effects or hepatitis flares?
Because Mavyret is used to treat hepatitis C, liver status matters. People with advanced liver disease or those who develop worsening liver function symptoms during treatment should be evaluated quickly. Your prescriber may monitor labs before and during therapy. [1]
What should I know about side effects if I also take other medicines?
Drug interactions can affect how your body handles treatment or can worsen liver stress for some combinations. Tell your clinician about all medicines, including over-the-counter drugs and supplements, before starting Mavyret. This helps reduce the risk of side effects linked to interactions. [1][2]
How long do side effects last after starting or stopping Mavyret?
Most side effects, when they happen, occur during treatment and tend to improve once therapy is completed. If symptoms continue or worsen after finishing treatment, you should contact your healthcare team. [1][2]
Where can I find the full side-effect list and details?
The most complete and up-to-date information is in the prescribing information and patient materials for Mavyret, which list common and less common adverse reactions and warnings. [1][2]
Sources:
1. https://www.rxabbvie.com/pdf/mavyretprescribinginformation.pdf
2. https://www.mavyret.com/side-effects.html