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Lipitor (atorvastatin) starts lowering cholesterol within 2 weeks of beginning treatment, with maximum effects typically reached after 4 weeks at the prescribed dose.[1][2] Patients often see low-density lipoprotein (LDL) cholesterol drop by 30-50% within those first 4 weeks, depending on dose and individual factors like baseline levels. Full benefits require consistent daily use, and doctors usually check levels after 4-12 weeks to adjust dosing.[1][3] Sources [1]: FDA Lipitor Label [2]: Drugs.com - Lipitor Timeline [3]: DrugPatentWatch.com - Atorvastatin Profile
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