What side effects does Skyrizi (risankizumab) cause?
Skyrizi’s most common side effects are usually mild and related to the immune system’s activity. The main risks reported include infections and injection-site reactions.
Commonly reported side effects include:
- Upper respiratory tract infections (such as common cold–type symptoms)
- Injection-site reactions (for example redness, pain, swelling) [1]
Less common but important side effects involve infections that can be more serious in some people, since Skyrizi targets a key immune pathway (IL-23). [1]
What are the serious side effects and “call your doctor” symptoms?
Because Skyrizi can increase infection risk, seek medical advice promptly if you develop signs of infection, such as:
- Fever or chills
- Persistent cough or shortness of breath
- Burning or pain when urinating
- Unusual fatigue or worsening illness
If you’re already prone to infections (or have had tuberculosis), your clinician may screen you before treatment and monitor you during therapy. [1]
Does Skyrizi increase infection risk or reactivation of TB?
Yes. Products like Skyrizi that suppress parts of the immune system can raise the risk of infections. Prescribers typically check for tuberculosis (TB) before starting biologic treatment, and they may monitor for TB during treatment if there are risk factors. [1]
What side effects are patients asking about most?
People commonly ask about:
- Whether Skyrizi makes colds and respiratory infections more frequent (it can) [1]
- Whether injection reactions are expected (they can occur) [1]
- What to do if they get sick after an injection (contact the prescriber, especially if symptoms are significant or persistent) [1]
How do side effects compare to other psoriasis biologics?
Skyrizi is one of several IL-23 pathway biologics. Side effects and risks often overlap across biologics, especially around infection risk and injection reactions. Exact frequencies and patient experiences can differ by drug and dose. [1]
When should Skyrizi be stopped or delayed?
Do not stop Skyrizi on your own. In many cases, clinicians may delay a dose during an active significant infection, but the right step depends on the severity and type of illness. Contact your prescriber promptly if you develop infection symptoms. [1]
Sources
- https://www.skyrizi.com/about-skyrizi/safety