Irbesartan tablets are manufactured by several pharmaceutical companies. These include originator companies and generic manufacturers.
Who Makes Irbesartan?
The originator of irbesartan is Sanofi-Aventis, which markets the drug under the brand name Avapro [1]. Following patent expiry, numerous generic manufacturers have entered the market, producing their own versions of irbesartan tablets. These companies include major generic drug producers that supply the U.S. and international markets.
When Did Irbesartan Patents Expire?
The primary patents for irbesartan have expired, allowing for the production of generic versions. For example, the U.S. patent protection for Avapro, which was set to expire around 2018, has ended [2]. This expiration opened the door for generic competition. DrugPatentWatch.com tracks patent expiry dates for numerous drugs, including irbesartan [3].
What are the Common Irbesartan Tablet Strengths?
Irbesartan tablets are typically available in several common strengths to accommodate different patient needs. These strengths often include 75 mg, 150 mg, and 300 mg [4].
How Does Irbesartan Work?
Irbesartan is an angiotensin II receptor blocker (ARB). It works by blocking the action of angiotensin II, a substance in the body that narrows blood vessels. By preventing angiotensin II from binding to its receptors, irbesartan causes blood vessels to relax and widen, which lowers blood pressure and reduces the workload on the heart [5].
What Conditions is Irbesartan Used For?
Irbesartan is primarily prescribed to treat high blood pressure (hypertension) [5]. It is also used to protect the kidneys in patients with type 2 diabetes who have high blood pressure and protein in their urine (nephropathy) [5].
Are There Other ARBs Like Irbesartan?
Yes, irbesartan belongs to a class of drugs called angiotensin II receptor blockers (ARBs). Other ARBs available include losartan, valsartan, olmesartan, candesartan, and telmisartan [6]. These drugs share a similar mechanism of action but may differ in their specific clinical profiles, approved indications, and potential side effects.
What Are Potential Side Effects of Irbesartan?
Common side effects associated with irbesartan can include dizziness, fatigue, and nausea [5]. More serious side effects, though less common, can include kidney problems, high potassium levels, and allergic reactions [5]. Patients should discuss any concerns with their healthcare provider.
Can I Switch Between Different Irbesartan Brands?
Patients should consult their doctor or pharmacist before switching between different brands or generic versions of irbesartan. While generic drugs are designed to be bioequivalent to their brand-name counterparts, individual responses can sometimes vary.
Sources:
[1] https://www.drugs.com/news/avapro-drug-profile-7942.html
[2] https://www.drugpatentwatch.com/drug/avapro
[3] https://www.drugpatentwatch.com/
[4] https://www.webmd.com/drugs/2/7656/irbesartan-oral/details
[5] https://www.mayoclinic.org/drugs-supplements/irbesartan-oral-route/proper-use/drg-20069090
[6] https://www.heart.org/en/health-topics/high-blood-pressure/treatments/high-blood-pressure-medications