Stomach Issues with Aspirin and Vascepa: What You Need to Know
Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), and Vasceva (icosapent ethyl), a prescription omega-3 fatty acid, are two medications with different mechanisms of action, but both have been associated with stomach issues in some patients.
Why are stomach issues a concern with Aspirin?
Aspirin is known to cause stomach problems in some individuals, including heartburn, acid reflux, and stomach ulcers [1]. This is because aspirin can irritate the lining of the stomach and increase the production of stomach acid. Long-term use of aspirin or high doses can increase the risk of stomach ulcers and bleeding [2].
Can Vascepa cause stomach issues?
Vasceva, a prescription omega-3 fatty acid, is commonly used to reduce triglyceride levels in patients with hypertriglyceridemia. While generally well-tolerated, Vasceva can cause gastrointestinal side effects, including nausea, diarrhea, and vomiting [3]. However, serious stomach issues like stomach ulcers or bleeding are rare with Vasceva.
Comparing stomach issues with Aspirin and Vascepa: What's the difference?
In clinical trials, patients taking Vasceva were more likely to experience gastrointestinal adverse events (GI AE) compared to those taking a placebo. However, the severity of these events was generally mild to moderate [4]. In contrast, aspirin has been associated with a higher risk of GI bleeding and ulcers, particularly with long-term use or high doses.
Are stomach issues a contraindication for Aspirin and Vascepa?
No, stomach issues are not a contraindication for Aspirin or Vasceva. However, patients taking either medication should be closely monitored for signs of stomach problems, such as heartburn, acid reflux, or stomach pain. Your healthcare provider may recommend lifestyle changes, such as eating smaller, more frequent meals, or taking the medication with food to reduce gastrointestinal side effects.
What are the alternatives if I experience stomach issues with Aspirin or Vascepa?
If you experience stomach issues with Aspirin or Vascepa, talk to your healthcare provider about alternative medications or dosage adjustments. For example, you may consider switching to a different NSAID or taking a proton pump inhibitor (PPI) to reduce stomach acid production.
Sources:
[1] US Food and Drug Administration. (2022). Aspirin. Retrieved from https://www.fda.gov/drugs/information-healthcare-professionals/fda-labeling/aspirin
[2] Gastrointestinal Society. (n.d.). Aspirin and stomach ulcers. Retrieved from https://www.gastrointestinal.ca/en/aspirin-and-stomach-ulcers
[3] Vascepa (Icosapent Ethyl). (n.d.). Prescribing Information. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/207934s016lbl.pdf
[4] Amarin Corporation. (2020). Vascepa (Icosapent Ethyl) Post-Marketing Safety Data. Retrieved from https://www.amarincorp.com/investors/quarterly-reports/default.aspx