Initial Dose for High Cholesterol
Doctors typically start with 10 mg or 20 mg of Lipitor (atorvastatin) once daily for adults with high cholesterol, taken any time of day with or without food. This applies to primary hyperlipidemia or mixed dyslipidemia, aiming to lower LDL cholesterol by 30-50% depending on the dose.[1]
Adjusting the Dose
If the initial dose doesn't lower LDL enough after 2-4 weeks, increase to 40 mg daily. The maximum is 80 mg once daily for patients needing more aggressive reduction, like those with coronary heart disease. Target LDL below 100 mg/dL (or below 70 mg/dL for high-risk patients).[1][2]
Doses for Specific Groups
- Elderly (65+): Start at 10 mg; same max as adults.
- Kidney issues: No adjustment needed unless severe; monitor closely.
- Children (10+ with familial hypercholesterolemia): 10-20 mg daily; max 20 mg for girls, 40 mg for boys post-puberty.[1]
| Patient Type | Starting Dose | Max Dose |
|--------------|---------------|----------|
| Most adults | 10-20 mg | 80 mg |
| High-risk CVD | 20-40 mg | 80 mg |
| Kids 10-17 | 10 mg | 20-40 mg |
Factors Influencing the Dose
Dose depends on baseline LDL, cardiovascular risk, other meds (e.g., lower if on cyclosporine), ethnicity (Asians may need 50% reduction), and response. Always check liver enzymes before starting and as needed.[1][2]
Common Side Effects at Higher Doses
Muscle pain rises above 40 mg; rare rhabdomyolysis at 80 mg. Report unexplained weakness.[1]
[1]: Lipitor Prescribing Information (Pfizer)
[2]: Drugs.com - Atorvastatin Dosage