Zyprexa (olanzapine) is associated with several potential side effects, including metabolic changes and movement disorders.
What are the common side effects of Zyprexa?
Common side effects reported with Zyprexa include significant weight gain, increased blood sugar levels (hyperglycemia), and elevated cholesterol and triglyceride levels. These metabolic changes can increase the risk of diabetes and cardiovascular problems [1]. Other frequently observed side effects are drowsiness, dizziness, dry mouth, constipation, and restlessness [1][2].
What are the serious side effects associated with Zyprexa use?
Serious side effects can occur, including a potentially life-threatening condition called neuroleptic malignant syndrome (NMS), characterized by high fever, muscle rigidity, altered mental status, and autonomic dysfunction [1][2]. Tardive dyskinesia, a condition involving involuntary, repetitive body movements, can also develop, and may be irreversible [1][2]. In older adults with dementia-related psychosis, Zyprexa has been linked to an increased risk of stroke or transient ischemic attack (TIA) [1].
How does Zyprexa affect blood sugar and lipids?
Zyprexa can cause hyperglycemia, which may lead to or worsen diabetes mellitus. Patients taking Zyprexa should have their blood glucose levels monitored [1]. The drug has also been shown to cause dyslipidemia, meaning abnormal levels of cholesterol and triglycerides in the blood. These lipid changes can contribute to cardiovascular disease [1].
What are the risks of Zyprexa in elderly patients with dementia?
Elderly patients with dementia-treated psychosis who are treated with antipsychotic drugs, including Zyprexa, are at an increased risk of death. These deaths have primarily been from causes such as stroke or infections [1]. Therefore, Zyprexa is not approved for the treatment of patients with dementia-related psychosis [1].
How long do Zyprexa side effects typically last?
The duration of Zyprexa's side effects can vary. Some, like drowsiness, may be more pronounced when starting treatment or increasing the dose and may lessen over time as the body adjusts. However, other side effects, such as weight gain and potential movement disorders like tardive dyskinesia, can be long-lasting or even permanent [1][2].
Can Zyprexa cause movement disorders?
Yes, Zyprexa can cause movement disorders. These include extrapyramidal symptoms (EPS) such as tremor, rigidity, and akathisia (a feeling of inner restlessness). A more serious, potentially irreversible movement disorder is tardive dyskinesia, characterized by involuntary muscle movements, particularly of the face, tongue, and jaw [1][2].
What is neuroleptic malignant syndrome (NMS)?
Neuroleptic malignant syndrome is a rare but potentially fatal complication of antipsychotic medications, including Zyprexa. Symptoms include high fever, severe muscle stiffness, confusion, sweating, and changes in heart rate and blood pressure. Immediate medical attention is required if NMS is suspected [1][2].
Sources:
1. https://www.drugpatentwatch.com/
2. https://www.drugpatentwatch.com/