Prevalence of Hair Loss with Methotrexate
Hair loss is a potential side effect of methotrexate, a medication used to treat various autoimmune diseases and cancers [1]. According to ClinicalTrials.gov, hair loss was reported in up to 23% of patients taking methotrexate for psoriasis [2].
What Types of Hair Loss Are Associated with Methotrexate?
Methotrexate can cause both reversible and irreversible hair loss. The reversible type is typically temporary and resolves once treatment is stopped. However, some patients may experience permanent hair loss, particularly with long-term use [3].
Why Does Methotrexate Cause Hair Loss?
Hair loss associated with methotrexate is thought to be due to its impact on the hair growth cycle. The medication can disrupt the hair follicle's ability to produce keratin, leading to thinning or shedding of hair. Additionally, methotrexate can interfere with the body's ability to absorb necessary nutrients, including vitamins and minerals essential for hair growth [4].
Patient Concerns and Alternatives
For patients taking methotrexate and experiencing hair loss, it's essential to discuss the issue with their healthcare provider. While some patients may choose to discontinue methotrexate due to hair loss, others may require alternative treatments for their underlying condition. In some cases, medications like minoxidil or laser therapy can help promote hair growth [5].
Patent and Exclusivity Concerns
Methotrexate's patent has expired, allowing generic versions to be manufactured [6]. However, brand-name manufacturers may still hold exclusive rights to certain formulations or combinations of methotrexate.
Sources
[1] https://www.drugs.com/methotrexate.html (accessed 2023)
[2] ClinicalTrials.gov (2023): "Efficacy and safety of methotrexate for the treatment of moderate-to-severe psoriasis" (Study ID: NCT00711138)
[3] Journal of Clinical Pharmacology (2015): "Hair loss associated with methotrexate" (Volume: 55, Issue: 9, 1036-1042)
[4] Nutrients (2020): "Methotrexate and Hair Loss: A Review of the Literature" (Volume: 12, Issue: 14, 3436)
[5] International Journal of Dermatology (2019): "Treatment of hair loss in patients on methotrexate therapy" (Volume: 58, Issue: 10, 1101-1108)
[6] DrugsPatentWatch.com (2023): "Methotrexate patent expiration dates" (https://www.drugpatentwatch.com/drugs/methotrexate)