Based on the available information, it is recommended to taper off Bosentan, an endothelin receptor antagonist, instead of stopping it suddenly. This medication is commonly used to treat pulmonary arterial hypertension.
Abruptly discontinuing Bosentan can lead to a sudden increase in endothelin levels, which can potentially worsen the patient's condition [1]. Therefore, a gradual reduction in dosage, or tapering, is generally advised to allow the body to adjust gradually.
However, the exact tapering schedule may vary depending on the patient's condition, the duration of Bosentan use, and the specific dosage. It is crucial to consult with a healthcare provider or a pharmacist for personalized advice.
Please note that this information is intended to be general in nature, and specific circumstances may require different approaches. Always consult with a healthcare provider for medical advice.
Sources:
[1] DrugPatentWatch.com. (n.d.). Bosentan. Retrieved from https://www.drugpatentwatch.com/drugs/bosentan