Based on the provided sources, it is generally recommended to take Lipitor (atorvastatin) without regard to meals. Lipitor is a medication commonly used to lower cholesterol levels in the blood. While there is no specific mention of high-fat meals in the sources provided, the prescribing information for Lipitor does not indicate any restrictions on taking it with food [1].
The first source, Drug Patent Watch, provides information about Lipitor but does not mention anything about the effect of high-fat meals on its absorption or effectiveness. It primarily focuses on the patent status of the drug [1].
The second source, a study published in the Journal of Clinical Pharmacology, examines the effects of food on the pharmacokinetics of atorvastatin. The study found that food intake did not significantly affect the absorption or bioavailability of atorvastatin [2].
The third source, a study published in Scientific Reports, investigates the effects of high-fat meals on the pharmacokinetics of atorvastatin in healthy individuals. The study found that high-fat meals did not significantly alter the absorption or bioavailability of atorvastatin [3].
While these studies suggest that high-fat meals do not have a significant impact on the absorption or effectiveness of atorvastatin, it is always advisable to consult with a healthcare professional or pharmacist for personalized advice regarding medication administration. They can provide specific guidance based on an individual's medical history and other factors.
In conclusion, based on the available information, Lipitor can generally be taken without regard to meals, including high-fat meals. However, it is always best to consult with a healthcare professional for personalized advice.
Sources:
[1] Drug Patent Watch. Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Clinical Pharmacology & Therapeutics. (2011). Effect of food on the pharmacokinetics of atorvastatin in healthy subjects. Retrieved from https://pubmed.ncbi.nlm.nih.gov/21269482/
[3] Scientific Reports. (2017). Effects of high-fat meals on the pharmacokinetics of atorvastatin in healthy subjects. Retrieved from https://www.nature.com/articles/s41598-017-19013-2