What is the typical frequency of liver enzyme increases with tigecycline?

With tigecycline, elevations in liver enzymes are fairly common, but usually mild-to-moderate. In clinical studies, ALT and/or AST elevations occurred in roughly ~10–20% of patients (depending on the trial population and how “increased” is defined—e.g., any increase vs. ≥3× the upper limit of normal).

A few practical points:

• Bilirubin elevations can also occur, and more clinically significant liver test abnormalities (e.g., marked transaminase rise or cholestatic patterns) are less common.
• These abnormalities are typically asymptomatic and reversible after stopping in many cases, but monitoring is important.

If you tell me the dose (e.g., standard vs higher), patient setting (ICU vs other), and the enzyme threshold you’re asking about (any increase vs ≥3× ULN), I can narrow the estimate to match that context.