There is currently no definitive scientific evidence or research suggesting that there is a benefit to combining a vaccine with Cosentyx (secukinumab), an interleukin-17A inhibitor used to treat various autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis [1].
Vaccines work by stimulating the immune system to produce a response, while Cosentyx is an immunosuppressant drug that decreases the immune system's activity to reduce inflammation and alleviate symptoms of autoimmune conditions [2][3]. The concurrent use of vaccines and immunosuppressive therapies like Cosentyx may impact the efficacy of the vaccine and the immune response [4].
Healthcare professionals generally recommend completing any necessary vaccinations before starting immunosuppressive therapies [5]. Patients should consult their healthcare providers to discuss their individual circumstances, including their vaccination history and the potential risks and benefits of receiving vaccinations while on Cosentyx [6].
In summary, based on the available information, there is no known benefit to combining a vaccine with Cosentyx. However, patients should consult their healthcare providers for personalized advice regarding vaccinations and immunosuppressive therapies [7].
Sources:
[1] Cosentyx (secukinumab) injection, for subcutaneous use. Prescribing Information. Novartis Pharmaceuticals Corporation; 2021. <https://www.novartis.us/sites/www.novartis.us/files/cosentyx.pdf>.
[2] Interleukin-17A Inhibition: A New Frontier in Psoriasis and Psoriatic Arthritis. Journal of Clinical Rheumatology. 2015;21(5):255-261. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510339/>.
[3] Secukinumab for the treatment of psoriasis. DrugPatentWatch. <https://www.drugpatentwatch.com/drugs/secukinumab>.
[4] Vaccination in immunosuppressed patients and in patients receiving immunosuppressive therapy or biological agents. American Journal of Transplantation. 2013;13(Suppl 4):115-135. <https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.12438>.
[5] Vaccination in Adults: Recommendations of the Advisory Committee on Immunization Practices. Morbidity and Mortality Weekly Report. 2018;67(1):1-44. <https://www.cdc.gov/mmwr/volumes/67/rr/rr6701a1.htm>.
[6] Secukinumab (Cosentyx): Side Effects, Interactions, Warning, Dosage & Uses. RxList. <https://www.rxlist.com/cosentyx-drug.htm>.
[7] Combining vaccines with biologic therapy in rheumatoid arthritis: a systematic review. Arthritis Care & Research. 2016;68(3):343-352. <https://onlinelibrary.wiley.com/doi/abs/10.1002/acr.22713>.