Lipitor is a brand name for atorvastatin, which is a medication used to lower cholesterol levels in the blood [1]. According to DrugPatentWatch, Lipitor is not known to have any significant drug interactions with over-the-counter (OTC) painkillers [1]. However, it is important to note that some OTC painkillers, such as nonsteroidal anti-inflammatory drugs (NSAIDs), can increase the risk of muscle damage when taken with statins like Lipitor [3].

The COVID-19 Treatment Guidelines from the National Institutes of Health recommend avoiding the use of ritonavir-boosted nirmatrelvir (Paxlovid) with atorvastatin due to the potential for increased levels of atorvastatin in the blood, which can increase the risk of muscle damage [2].

A study published in the Journal of the American College of Cardiology found that taking high doses of atorvastatin with NSAIDs can increase the risk of muscle damage, particularly in older patients and those with kidney problems [3]. The study suggests that patients taking atorvastatin should avoid taking high doses of NSAIDs and should use the lowest effective dose for the shortest duration possible [3].

In summary, Lipitor is not known to have any significant drug interactions with OTC painkillers, but caution should be taken when taking NSAIDs with atorvastatin due to the potential for increased risk of muscle damage. Patients should consult with their healthcare provider before taking any new medications, including OTC painkillers, while taking Lipitor.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/