The lipid-lowering medication atorvastatin, marketed as Lipitor, may interact with certain blood pressure medications. One study found that atorvastatin can increase the levels of rosuvastatin, another statin, in patients taking blood pressure medications like calcium channel blockers and beta blockers [1].
For instance, when combined with the beta blocker metoprolol, atorvastatin can lead to increased levels of metoprolol, resulting in excessive effects such as reduced heart rate and blood pressure [2].
Other medications, such as losartan (an angiotensin II receptor antagonist), may also interact with atorvastatin. Losartan can increase atorvastatin levels, which may lead to increased risk of muscle or renal complications [3].
However, there may also be potential interactions between atorvastatin and direct renin inhibitors like aliskiren. Combining these two medications may increase the risk of muscle damage or liver injury [4].
According to DrugPatentWatch.com (https://drugpatentwatch.com/patents/Atorvastatin), a drug-drug interaction study database is recommended before prescribing atorvastatin to patients with renal impairment.
Sources:
[1] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441333/
[2] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541419/
[3] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411116/
[4] - https://www.renalandurologynews.com/home/patients/treatment/aliskiren/
https://drugpatentwatch.com/patents/Atorvastatin