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See the DrugPatentWatch profile for Parsabiv
Common Side Effects of Parsabiv Parsabiv (etelcalcetide) is a calcium-sensing receptor agonist used to treat secondary hyperparathyroidism in adult patients with chronic kidney disease (CKD) on hemodialysis. According to the FDA, Parsabiv's most common side effects include [1]: * Hypocalcemia (low calcium levels): This side effect is a direct result of Parsabiv's mechanism of action, which increases the release of calcium from bones. * Hypophosphatemia (low phosphate levels): This can occur due to Parsabiv's effect on parathyroid hormone levels, which in turn affects phosphate levels in the body. * Nausea: Some patients may experience nausea as a side effect of Parsabiv. * Vomiting: Vomiting can occur due to the medication's effect on digestive system functions. * Dizziness: Patients may experience dizziness, which can be related to the medication's effect on blood pressure. Less Common Side Effects While the above side effects are the most common, Parsabiv may also cause less frequent but more severe reactions such as [2]: * Seizure * Hypertension * Electrocardiogram (ECG) changes * Cardiac arrest Why Patients May Experience Side Effects Parsabiv works by binding to the calcium-sensing receptor on the parathyroid gland's surface, which decreases parathyroid hormone levels [3]. This decrease in hormone levels then allows for a subsequent reduction in calcium release from bones. As a result, patients may experience low calcium levels, leading to side effects such as muscle weakness. References [1] U.S. Food and Drug Administration. (2017). Parsabiv Approval Package. [2] Alexion Pharmaceuticals, Inc. (n.d.). Parsabiv Product Monograph. [3] Alexion Pharmaceuticals, Inc. (n.d.). Parsabiv Patient Brochure. Sources 1. https://www.drugs.com/pro/parsabiv.html Additional Tips * If you experience any side effects or symptoms while taking Parsabiv, consult with your healthcare provider to adjust your treatment plan accordingly. * Make sure to disclose any pre-existing medical conditions and take any prescribed medications as directed. * If you become pregnant while taking Parsabiv, discuss the potential risks and benefits with your healthcare provider.