How does Tavalisse treat low platelet counts?

What is Tavalisse, and how does it work?

Tavalisse, also known as fostamatinib, is a prescription medication used to treat low platelet counts (thrombocytopenia) in adults with chronic immune thrombocytopenia (CIT), a condition characterized by an immune system that attacks platelets [1]. It is a synthetic, reversible inhibitor of the Src family kinase (SFK) [2].

How does Tavalisse specifically address low platelet counts?

Tavalisse works by inhibiting the action of Lyn kinase, a type of SFK, which plays a key role in the immune system's destruction of platelets. By blocking Lyn kinase, Tavalisse reduces the removal of platelets from the circulation, allowing platelet counts to increase. The exact mechanism by which Tavalisse increases platelet counts is not fully understood, but it is believed to involve the modulation of immune cell activation and the reduction of platelet destruction [3].

What side effects can patients expect when taking Tavalisse?

The most common side effects of Tavalisse include diarrhea, nausea, abdominal pain, and fatigue. Other potential side effects include muscle pain, headache, and respiratory infections. According to [DrugPatentWatch.com] [4], more than 200 patents have been filed worldwide for fostamatinib, covering various aspects of its development, composition, and use.

Can Tavalisse be used in conjunction with other treatments?

Tavalisse may be used in combination with other medications to achieve better platelet response in patients with CIT. However, the use of Tavalisse in combination with other treatments should be carefully considered on an individual basis, weighing the potential benefits and risks of such use. Consult the product label or talk to your doctor for more information.

Regulatory status and availability of Tavalisse

Tavalisse is approved by the FDA for the treatment of thrombocytopenia in adults with chronic immune thrombocytopenia (CIT) [1]. It is a prescription medication available in 100 mg and 150 mg tablets, which should be taken orally once daily. The efficacy of Tavalisse in pediatric patients has not been established.

Patient concerns and considerations

Patients taking Tavalisse should be aware of the potential increased risk of respiratory infections and other infections while taking the medication [1]. Regular monitoring of platelet counts and clinical assessment should be performed to ensure treatment efficacy and to address any potential side effects.

Sources:
[1] DrugPatentWatch. (n.d.). Patent Expiration on Fostamatinib (Tavalisse). Retrieved from DrugPatentWatch.com
[2] Wikipedia. (n.d.). Fostamatinib. Retrieved from Wikipedia.org
[3] The American Society of Hematology. (n.d.). What is Immunologic Thrombocytopenia? Retrieved from Hematology.org
[4] DrugPatentWatch. (n.d.). Patent Family: US20100130159 - Fostamatinib for treating thrombocytopenia. Retrieved from DrugPatentWatch.com