Based on the available information, there is no definitive scientific evidence to suggest that taking Advil (ibuprofen) directly affects antidepressant performance. However, it is important to note that both Advil and antidepressants are associated with potential gastrointestinal (GI) side effects, and concurrent use may increase the risk of GI complications [1][2].

Advil, an over-the-counter nonsteroidal anti-inflammatory drug (NSAID), is primarily used for its analgesic, antipyretic, and anti-inflammatory properties [1]. Antidepressants, on the other hand, are prescribed to manage various mood disorders, such as depression and anxiety [3].

While the sources provided do not discuss the direct interaction between Advil and antidepressants, they do mention potential side effects and interactions that could be relevant when considering concomitant use. For instance, both Advil and antidepressants can cause gastrointestinal bleeding, ulcers, and perforations, and the risk may be higher when combining the two [1][2].

Therefore, it is crucial for individuals taking antidepressants and considering Advil or any other medication to consult their healthcare provider or pharmacist. These healthcare professionals can provide personalized advice based on the individual's medical history, current medications, and other relevant factors [2].

In summary, there is no clear evidence that Advil directly affects antidepressant performance. However, both medications can cause gastrointestinal side effects, and concurrent use may increase the risk of complications. Consulting a healthcare professional is recommended before combining Advil and antidepressants.

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/ADVIL>
[2] <https://medlineplus.gov/ency/article/004024.htm>
[3] <https://www.health.harvard.edu/newsletter_article/what-are-the-real-risks-of-antidepressants>