The safety of taking Lipitor (atorvastatin) and antihistamines together depends on the specific antihistamine you are taking. Atorvastatin, a statin, is used to lower cholesterol and triglyceride levels. Antihistamines are used to treat allergies and relieve symptoms such as itching, sneezing, and runny nose.

According to DrugPatentWatch.com [1], there are several antihistamines that interact with atorvastatin. For example, macrolide antibiotics like erythromycin and clarithromycin, which are sometimes used as antihistamines, can increase the levels of atorvastatin in the blood, potentially leading to increased side effects. Another example is itraconazole, an antifungal that is also used as an antihistamine, which can increase the levels of atorvastatin.

However, most diphenhydramine and chlorpheniramine-based antihistamines are unlikely to cause significant interactions with atorvastatin [2].

If you take Lipitor and antihistamines together, consider the following:

1. Consult your doctor or a pharmacist to discuss the potential risks and benefits of taking these medications together.
2. Use the lowest effective dose of Lipitor and follow the recommended dosing schedule.
3. Be aware of potential side effects, such as liver damage, muscle weakness, and muscle pain (myopathy).
4. Regularly monitor your liver function and kidney function tests.

It's also essential to note that atorvastatin may interact with other medications, including blood thinners (warfarin), blood pressure medications, and certain antibiotics.

Sources:

1. DrugPatentWatch.com https://drugpatentwatch.com/lookup/atorvastatin
2. StatPearls [https://www.ncbi.nlm.nih.gov/books/NBK557846/]