Alcohol can impair nutrient absorption in several ways. First, alcohol can damage the cells in the stomach and intestines, which can lead to malabsorption of nutrients [1]. Additionally, alcohol can increase the production of stomach acid, which can further damage the lining of the stomach and intestines [1].

Alcohol can also interfere with the absorption of nutrients by affecting the production and activity of digestive enzymes. For example, alcohol can inhibit the activity of enzymes that are necessary for the absorption of fats and fat-soluble vitamins [1].

Furthermore, alcohol can increase the excretion of nutrients through the urine, which can lead to deficiencies over time [1]. This is because alcohol increases the production of a hormone called antidiuretic hormone (ADH), which causes the kidneys to retain water and excrete more electrolytes and nutrients [1].

Additionally, alcohol can interfere with the metabolism of nutrients by affecting the activity of enzymes in the liver [1]. For example, alcohol can inhibit the activity of enzymes that are necessary for the metabolism of certain B vitamins, such as thiamin and folate [1].

In summary, alcohol can impair nutrient absorption by damaging the cells in the stomach and intestines, inhibiting the activity of digestive enzymes, increasing the excretion of nutrients through the urine, and interfering with the metabolism of nutrients in the liver.

Sources:

1. <https://www.drugpatentwatch.com/drug/alcohol-abuse-treatment-and-prevention-drugs>