What organs does ibuprofen damage?
Ibuprofen (a nonsteroidal anti-inflammatory drug, NSAID) mainly harms the stomach and kidneys. It can also increase cardiovascular risk and raise blood pressure in some people.
Does ibuprofen damage the stomach or gut?
Yes. Ibuprofen can irritate the stomach lining and increase the risk of gastritis, ulcers, and GI bleeding. These effects are more likely with higher doses, older age, a history of ulcers/bleeding, and when combined with other ulcer-risk drugs (like other NSAIDs or blood thinners).
Does ibuprofen damage the kidneys?
Yes. Ibuprofen can reduce blood flow to the kidneys, which may lead to acute kidney injury—especially in people who are dehydrated, have chronic kidney disease, older adults, or those taking certain blood-pressure/heart medications (for example, ACE inhibitors/ARBs or diuretics).
What other organs are affected?
Ibuprofen can affect the cardiovascular system indirectly (raising risk of heart attack or stroke in some patients, particularly with higher doses or longer use). It can also worsen control of blood pressure in some people.
Who is at higher risk of ibuprofen organ damage?
Risk is higher for people with a history of stomach ulcers or bleeding, kidney disease, dehydration, older age, and those using interacting medicines (other NSAIDs, anticoagulants, corticosteroids, or certain blood-pressure meds).