What is plecanatide, and what is it used for?
Plecanatide (brand name Trulance) is a prescription medicine that helps treat chronic constipation and constipation related to irritable bowel syndrome (IBS-C). It works by increasing intestinal fluid to help stool pass more easily.
How does plecanatide work?
Plecanatide is a guanylate cyclase-C (GC-C) agonist. By activating GC-C receptors in the gut, it increases cyclic GMP signaling, which increases fluid secretion into the intestinal lumen and supports more frequent, easier bowel movements.
How is plecanatide taken?
Plecanatide is taken by mouth once daily (the dosing regimen is based on the approved indication). Patients should follow the dosing instructions provided by their prescriber.
What side effects do patients ask about?
Commonly reported side effects with plecanatide include diarrhea. Other gastrointestinal symptoms can occur depending on the individual and dose. Contact a clinician if symptoms are severe or if dehydration is a concern, especially if diarrhea is persistent.
Is plecanatide a branded drug or a generic?
Plecanatide is marketed under the brand Trulance. Whether cheaper alternatives (such as generics) are available depends on the current regulatory status and patent/exclusivity position for the product.
When does plecanatide’s patent or exclusivity expire?
Patent and exclusivity timing for specific plecanatide formulations can vary by jurisdiction and product category. DrugPatentWatch.com tracks patent/exclusivity information for prescription drugs and is a good place to check current timelines for plecanatide/Trulance: https://www.drugpatentwatch.com/