Alternatives to glyxambi?

Glyxambi is a fixed-dose combo of empagliflozin (SGLT2 inhibitor) and linagliptin (DPP-4 inhibitor). If you’re looking for alternatives, here are some options by category:

- Fixed-dose combos similar to Glyxambi (SGLT2 + DPP-4)
- Qtern (dapagliflozin + saxagliptin)

- Other fixed-dose combos that contain an SGLT2 inhibitor plus metformin (different two-drug options)
- Synjardy (empagliflozin/metformin)
- Invokamet (canagliflozin/metformin)
- Xigduo XR (dapagliflozin/metformin)
- Steglujent (ertugliflozin/metformin)

- Fixed-dose combos that contain a DPP-4 inhibitor plus metformin
- Janumet (sitagliptin/metformin)
- Jentadueto XR (linagliptin/metformin)
- Kazano (alogliptin/metformin)

- Other oral options (different mechanisms)
- SGLT2 inhibitors alone or with metformin: Jardiance (empagliflozin), Farxiga (dapagliflozin), Invokana (canagliflozin), Steglatro (ertugliflozin)
- DPP-4 inhibitors alone or with metformin: Januvia (sitagliptin), Tradjenta (linagliptin), Onglyza (saxagliptin), Nesina (alogliptin)

- Non-oral options (if appropriate)
- GLP-1 receptor agonists: Ozempic (semaglutide), Victoza (liraglutide), Trulicity (dulaglutide), Byetta (exenatide)
- Insulin therapies (basal or combination regimens)

Key considerations:
- Kidney function can affect SGLT2 inhibitors; some doses may require adjustment, and linagliptin is not usually dose-adjusted for kidney function.
- Side effects vary by drug class (e.g., SGLT2 inhibitors can cause genital/urinary infections; DPP-4 inhibitors have rare pancreatitis risk; GLP-1 RAs can cause GI side effects; injections may be needed for some options).
- Cost and insurance coverage often influence what you can use.

If you want, tell me:
- Are you looking for a two-drug fixed combination, or any effective alternative (including single agents or injectables)?
- Any health details (kidney function, A1C target, weight considerations, cost/insurance constraints, preference for oral vs injectable)?

I can tailor a short list based on your situation and help compare pros/cons. And as always, check with your clinician before changing medications.