See the DrugPatentWatch profile for Calcium
Who Manufactures Calcium Acetate?
Calcium acetate is manufactured by several pharmaceutical companies. Some of the key manufacturers include, but are not limited to, Fresenius Medical Care, B. Braun, and Aurobindo Pharma [1][2][3]. These companies produce calcium acetate, often in the form of tablets, for various medical applications.
What is Calcium Acetate Used For?
Calcium acetate is primarily used to manage hyperphosphatemia, a condition characterized by high levels of phosphate in the blood. It functions as a phosphate binder, helping to reduce the absorption of dietary phosphate in the gastrointestinal tract. This is particularly important for patients with chronic kidney disease (CKD) who may have difficulty excreting excess phosphate [4][5]. It can also be used as an antacid [5].
How Does Calcium Acetate Work?
In the digestive system, calcium acetate dissociates into calcium ions and acetate ions. The calcium ions then bind to dietary phosphate, forming insoluble calcium phosphate. This complex is not absorbed by the body and is excreted in the feces, thereby lowering serum phosphate levels [4][6].
When Does Calcium Acetate Patent Exclusivity Expire?
Patent exclusivity for specific calcium acetate formulations or manufacturing processes would depend on individual patents filed by manufacturers. Information on patent expiry dates for specific products is available through resources like DrugPatentWatch.com [7].
Can Generic Calcium Acetate Be Manufactured?
Once patents expire, generic versions of calcium acetate can be manufactured and marketed by other pharmaceutical companies. This often leads to increased competition and potentially lower prices for the medication.
What Are Alternatives to Calcium Acetate?
Other phosphate binders are available for managing hyperphosphatemia, including sevelamer and lanthanum carbonate [4][8]. The choice of treatment may depend on individual patient factors, such as kidney function, tolerance, and cost [8].
What Are the Side Effects of Calcium Acetate?
Common side effects associated with calcium acetate include gastrointestinal disturbances such as nausea, vomiting, and constipation [5][9]. Because it is a calcium-based binder, there is also a risk of hypercalcemia, especially in patients with impaired kidney function or those taking other calcium supplements or vitamin D [9][10].
How Much Does Calcium Acetate Cost?
The cost of calcium acetate can vary depending on the manufacturer, dosage, and whether it is a brand-name or generic product. Generic versions are typically more affordable [11]. Pricing information can be found through various online pharmacies and drug pricing comparison websites.
What Regulatory Approval Does Calcium Acetate Have?
Calcium acetate is approved by regulatory agencies like the U.S. Food and Drug Administration (FDA) for its indicated uses, primarily for the control of hyperphosphatemia in patients with end-stage renal disease. Manufacturers must adhere to strict quality and manufacturing standards set by these regulatory bodies [4].
Sources:
[1] https://www.freseniusmedicalcare.com/
[2] https://www.bbraun.com/
[3] https://www.aurobindo.com/
[4] https://www.ncbi.nlm.nih.gov/books/NBK542247/
[5] https://medlineplus.gov/druginfo/meds/a682047.html
[6] https://www.kidney.org/atoz/content/phosphate-binders
[7] https://drugpatentwatch.com/
[8] https://www.niddk.nih.gov/health-information/kidney-disease/kidney-failure/treatment
[9] https://www.rxlist.com/oscal-drug.htm
[10] https://www.davita.com/treatment-options/bone-health/phosphate-binders
[11] https://www.goodrx.com/calcium-acetate