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What is the recommended cosentyx dosage increase timeline?

See the DrugPatentWatch profile for cosentyx

Standard Cosentyx Starting Dosage

Cosentyx (secukinumab) for plaque psoriasis starts at 300 mg subcutaneously once weekly for the first 5 weeks (doses at Weeks 0, 1, 2, 3, 4). Maintenance follows at 300 mg every 4 weeks.[1]

Dosage Ramp-Up for Psoriatic Arthritis

Same initial 300 mg weekly for 5 weeks, then 300 mg every 4 weeks. For patients under 110 kg with inadequate response, stay at 300 mg; those over 110 kg may increase to 300 mg every 2 weeks after Week 4.[1]

Timeline for Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis

Loading: 150 mg (or 300 mg for faster response) at Weeks 0, 1, 2, 3, 4. Maintenance: 150 mg (or 300 mg) every 4 weeks starting Week 8.[1]

Adjustments for Hidradenitis Suppurativa

300 mg weekly for 4 weeks (Weeks 0-3), then every 4 weeks. Increase to 300 mg every 2 weeks if no improvement by Week 16.[1]

Pediatric Dosage Timelines (Ages 6+ for Psoriasis/Enthesitis-Related Arthritis)

Weight-based: Under 50 kg starts at 75 mg weekly for 5 weeks, then every 4 weeks; 50 kg+ uses adult 300 mg schedule.[1]

When to Increase Dosage

Increases occur only for inadequate response, typically assessed at Week 12-16 depending on condition. No automatic escalations; consult prescriber for weight-based or efficacy-driven changes. Max dose is 300 mg.[1]

[1] Cosentyx Prescribing Information, Novartis, https://www.cosentyx.com/



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