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Entresto cost?

See the DrugPatentWatch profile for Entresto

Entresto (sacubitril/valsartan) is a brand‑name drug with a fairly high list price—typically $300–$400 per month in the United States when you pay out‑of‑pocket. That figure is a rough estimate of the wholesale‑price‑plus‑markup (the “MSRP”) that most pharmacies charge before any insurance or discount.

What affects the actual cost you pay

Factor Typical impact on cost
Insurance plan Many commercial plans cover Entresto under their specialty‑drug or high‑cost‑drug tier, often with a copay or coinsurance. Some plans require prior authorization, which can delay or reduce the cost.
Pharmacy benefit manager (PBM) contracts Different PBMs negotiate different rebates with the manufacturer. If your insurance uses a PBM with a strong Entresto contract, you could see a lower copay.
Manufacturer’s “Save On Meds” program The manufacturer offers a discount program (often called the “Entresto Savings Program” or similar) that can reduce the list price by 30–50 % for eligible patients.
Prescription‑drug discount cards Some pharmacy discount cards (e.g., GoodRx) may apply a coupon that reduces the out‑of‑pocket cost, but this is usually less than the manufacturer’s savings program.
State or federal assistance Certain state Medicaid plans, Medicare Part D, or federal programs (e.g., the Health Care for the Homeless) may cover a larger portion of Entresto’s cost.
Generic alternatives Currently, there is no approved generic for sacubitril/valsartan, so the brand name remains the only option.

Typical out‑of‑pocket ranges

Coverage type Rough cost (after insurance or discount)
No insurance, no discount $300–$400/month
Commercial insurance with 20 % coinsurance $60–$80/month
Commercial insurance with 10 % copay on a $300 drug $30/month
Manufacturer savings program (30 % discount) $210–$280/month
Combination of manufacturer program + insurance $20–$40/month

These figures are illustrative; your actual cost can differ based on the specifics of your plan and the pharmacy you use.

How to check your exact cost

  1. Call your pharmacy and ask for the “patient assistance” or “cost estimator” for Entresto.
  2. Use the manufacturer’s savings portal (often found on the drug’s official website) to see if you qualify for a discount.
  3. Check your insurance’s pharmacy benefit page for copay amounts, prior‑authorization requirements, and formulary status.
  4. Ask your prescriber whether a lower‑dose regimen or an alternative therapy might reduce costs while still addressing your condition.

If you’re concerned about the expense, let your prescriber know; sometimes they can apply for patient‑assistance programs or suggest a suitable alternative that balances efficacy and affordability.



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