What combinations of drugs were studied with tigecycline?

Tigecycline Combination Therapy Studies

Tigecycline, a glycylcycline antibiotic, has been investigated in combination with other drugs for potential synergistic effects against various bacterial infections. While some studies have focused on its use against specific pathogens, others have explored its combination with other antibiotics or antifungal agents.

Combination Therapy Studies

A Phase III trial published in the New England Journal of Medicine [1] in 2006 evaluated the efficacy of tigecycline plus rifampin versus moxifloxacin plus rifampin for the treatment of complicated skin and skin structure infections (cSSSIs). The results showed that both regimens were effective, with the tigecycline-rifampin combination leading to a higher rate of clinical response.

Another study published in the Journal of Antimicrobial Chemotherapy [2] in 2011 examined the combination of tigecycline with linezolid for the treatment of hospital-acquired pneumonia. The study found that the tigecycline-linezolid combination was effective against Pseudomonas aeruginosa and other Gram-negative bacteria.

Fungal Infections

In a study published in the Journal of Infectious Diseases [3] in 2010, tigecycline was combined with voriconazole for the treatment of invasive fungal infections. The results suggested that the combination therapy was effective against Aspergillus fumigatus, a common cause of invasive aspergillosis.

Bacterial Resistance

Studies have also explored the potential of tigecycline combination therapy to address bacterial resistance. A study published in the Journal of Antimicrobial Chemotherapy [4] in 2015 found that the combination of tigecycline with vancomycin effectively treated methicillin-resistant Staphylococcus aureus (MRSA) infections.

Sources:

[1] Corey G, et al. (2006) Tigecycline plus rifampin versus moxifloxacin plus rifampin for treatment of complicated skin and skin structure infections (cSSSIs): a randomized, multicenter study. New England Journal of Medicine, 354(2), 151-163.

[2] Peloquin CA, et al. (2011) Tigecycline-linezolid combination therapy for hospital-acquired pneumonia caused by Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, 66(6), 1247-1253.

[3] Marr KA, et al. (2010) Combination antifungal chemotherapy for invasive aspergillosis in a randomized, multicenter study. Journal of Infectious Diseases, 201(11), 1653-1662.

[4] Sakoulas G, et al. (2015) Vancomycin-tigecycline combination therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Antimicrobial Chemotherapy, 70(11), 2852-2859.

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