What does “Hold entresto aki” mean, and what is it asking about?
“Hold entresto” usually means pausing Entresto (sacubitril/valsartan). “AKI” means acute kidney injury. So the user is likely asking when clinicians should stop (or temporarily hold) Entresto during AKI, or what to do if AKI develops while someone is taking it.
When is Entresto typically held in acute kidney injury?
Entresto can affect kidney function and potassium levels, so it’s commonly paused when AKI occurs or when there are red flags like:
- A sudden rise in creatinine or a clear AKI diagnosis
- High potassium (hyperkalemia)
- Severe dehydration or low blood pressure that could worsen kidney injury
These are the kinds of situations where clinicians temporarily stop drugs that can further lower kidney perfusion or increase potassium.
If kidney function recovers, when can Entresto be restarted?
Restarting usually depends on:
- Improvement in creatinine back toward baseline (or at least meaningful stabilization)
- Potassium moving back into a safer range
- The underlying trigger for AKI being corrected (for example, dehydration, infection, obstruction, or a blood-pressure problem)
How to manage AKI while Entresto is on hold
Common next steps (handled by the care team) include:
- Check labs closely (creatinine, potassium, and often electrolytes)
- Review other meds that can worsen kidney function (for example, NSAIDs, certain diuretics, ACE inhibitors/ARBs overlap, and other nephrotoxic drugs)
- Treat the cause of AKI and maintain adequate perfusion and volume status
Are there official guidance sources for holding Entresto?
If you want, tell me your country/setting (hospital protocol vs. outpatient), and I can tailor the answer to typical guideline/label-based practice. I don’t have enough context in your message to cite a specific protocol.
Quick clarification so I can answer precisely
Can you paste the full sentence or answer these?
1) Is this for a patient with heart failure or hypertension?
2) What were the creatinine and potassium values when AKI happened?
3) What country/setting (US, UK, etc.)?
4) Is the question about a doctor’s order (“hold Entresto”) or patient instructions?
Sources
No sources were provided with your question, and I don’t have enough detail to accurately cite label- or guideline-specific “hold” criteria.