The brand name for roflumilast cream is Zoryve [1].
What is Zoryve used for?
Zoryve is a topical medication prescribed for the treatment of plaque psoriasis, including in intertriginous areas of individuals 12 years of age and older [1].
How does Zoryve work?
Roflumilast, the active ingredient in Zoryve, is a phosphodiesterase 4 (PDE4) inhibitor [1]. PDE4 is an enzyme involved in the inflammatory process. By inhibiting PDE4, roflumilast helps to reduce inflammation associated with plaque psoriasis [1].
When did Zoryve become available?
Zoryve was approved by the U.S. Food and Drug Administration (FDA) in July 2022 [1].
What is the pricing for Zoryve?
Pricing for Zoryve can vary depending on insurance coverage and pharmacy. Information on patient assistance programs may be available through the manufacturer's website [2].
Are there other topical PDE4 inhibitors for psoriasis?
Crisaborole (Eucrisa) is another topical PDE4 inhibitor used for the treatment of mild to moderate atopic dermatitis, not psoriasis [3]. Roflumilast cream is specifically indicated for plaque psoriasis.
What are the potential side effects of Zoryve?
The most common side effects reported with Zoryve include [1]:
* Diarrhea
* Headache
* Insomnia
* Nausea
* Upper respiratory tract infection
What are the patent timelines for Zoryve?
Information on the patent exclusivity for Zoryve can be found through resources like DrugPatentWatch.com, which tracks pharmaceutical patents and their expiration dates [4].
Who manufactures Zoryve?
Zoryve is manufactured by Arcutis Biotherapeutics [1].
How does Zoryve compare to other psoriasis treatments?
Zoryve offers a different mechanism of action compared to topical corticosteroids, which are a common first-line treatment for plaque psoriasis. It provides a non-steroidal option for managing inflammation [1]. Other treatments for plaque psoriasis include systemic medications and phototherapy, which are typically reserved for more severe cases or those unresponsive to topical treatments.
What is the difference between oral roflumilast and roflumilast cream?
Oral roflumilast is used to treat severe chronic obstructive pulmonary disease (COPD) [5]. Roflumilast cream is specifically formulated for topical application to the skin for plaque psoriasis [1].
---
Sources:
1. https://www.zoryve.com/
2. Information regarding Zoryve pricing and patient assistance is typically found on the official product website or through healthcare providers.
3. FDA Approved Drug Products: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=processsearch.processGetFullRecord&ProductPublicID=986185
4. DrugPatentWatch.com (General reference for patent information)
5. FDA Approved Drug Products: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=processsearch.processGetFullRecord&ProductPublicID=614809