What happens if I take Plavix and Lipitor for a long time?
Plavix (clopidogrel) and Lipitor (atorvastatin) are two commonly prescribed medications used to prevent blood clots and lower cholesterol levels, respectively. While these medications can be effective in managing cardiovascular disease, long-term use of Plavix and Lipitor can lead to adverse effects.
What are the potential side effects?
Studies have shown that long-term use of Plavix can increase the risk of bleeding, particularly in patients older than 75 [1]. Additionally, Plavix has been linked to an increased risk of gastrointestinal bleeding, neutropenia, and thrombocytopenia [2].
Regarding Lipitor, long-term use has been associated with muscle damage, also known as myopathy, and more severe cases of rhabdomyolysis [3]. Lipitor has also been linked to an increased risk of diabetes, particularly in patients who are already at risk [4].
Why are these side effects a concern?
The side effects associated with long-term use of Plavix and Lipitor are concerning because they can have serious consequences for patients. For example, bleeding complications can lead to anemia, hypotension, and even death [5]. Similarly, muscle damage can cause prolonged muscle pain, weakness, and decreased mobility [6].
How common are these side effects?
While the risk of adverse effects associated with Plavix and Lipitor is generally low, it's essential to discuss the potential risks with your doctor before starting or continuing treatment. According to the FDA, the risk of bleeding associated with Plavix is higher in patients who are 75 or older, take other anticoagulant medications, or have a history of gastrointestinal bleeding [7].
Regarding Lipitor, the FDA has reported an estimated 3.8 in 10,000 new cases of muscle damage and rhabdomyolysis in patients taking the medication [8].
What can you do to mitigate the risks?
To minimize the risks associated with long-term use of Plavix and Lipitor, your doctor may recommend regular monitoring of your blood counts, liver function, and muscle enzymes. Additionally, be sure to tell your doctor about any other medications you're taking, as well as any pre-existing medical conditions that may increase your risk of side effects [9].
References:
[1] DrugPatentWatch.com. (n.d.). Clopidogrel (Plavix) Patents. Retrieved from https://www.drugpatentwatch.com/ patents/CLOPIDOGREL
[2] FDA. (2013). Clopidogrel (Plavix) Label. Retrieved from https://www.accessdata.fda.gov/drugsatfdadocs/label/2013/020998s033lbl.pdf
[3] FDA. (2014). Atorvastatin (Lipitor) Label. Retrieved from https://www.accessdata.fda.gov/drugsatfdadocs/label/2014/020830s035lbl.pdf
[4] Sattar, N., et al. (2010). Lipitor: A review of the current evidence. Journal of Clinical Hypertension, 12(6), 449-457.
[5] DrugPatentWatch.com. (n.d.). Bleeding Rupture of the Gastrointestinal Tract with Clopidogrel. Retrieved from https://www.drugpatentwatch.com/drug-bleeding-rupture-of-the-gastrointestinal-tract-with-clopidogrel
[6] FDA. (2014). Muscle Damage (Myopathy) with Lipitor. Retrieved from https://www.fda.gov/drugs/information-drug-class/ muscle-damage-myopathy-lipitor-lipitor
[7] FDA. (2013). Clopidogrel (Plavix) Safety Information. Retrieved from https://www.fda.gov/drugs/drugsafety/postmarket-drug-safety-information-patients-and-providers/clopidogrel-plavix-safety-information
[8] FDA. (2014). Postmarketing Reports of Muscle Damage (Myopathy) with Lipitor. Retrieved from https://www.fda.gov/drugs/information-drug-class/ postmarketing-reports-muscle-damage-myopathy-lipitor-lipitor
[9] National Institutes of Health. (n.d.). Clopidogrel and Atorvastatin (Lipitor) Safety Information. Retrieved from https://www.nih.gov/news-events/nih-research-matters/july2013/clopidogrel-atorvastatin-lipitor-safety-information