Advil and aspirin are both nonsteroidal anti-inflammatory drugs (NSAIDs) that are commonly used for pain relief. However, long-term use of these drugs can have potential risks and side effects.

Advil, which contains ibuprofen, is used to relieve pain and reduce inflammation. According to Drug Patent Watch [1], the drug has been on the market since 1984 and is available over-the-counter and by prescription. While it is generally considered safe when used as directed, long-term use can increase the risk of gastrointestinal bleeding, kidney damage, and cardiovascular events such as heart attack and stroke.

Aspirin is also an NSAID and is used for pain relief, fever reduction, and to prevent blood clots. According to Medical News Today [2], aspirin has been used for over a century and is available over-the-counter and by prescription. However, long-term use of aspirin can also increase the risk of gastrointestinal bleeding, kidney damage, and cardiovascular events. Additionally, aspirin can cause a rare but serious condition called Reye's syndrome in children and teenagers.

Healthline [3] suggests that people who need long-term pain relief should consider alternative treatments such as physical therapy, acupuncture, or cognitive behavioral therapy. Additionally, people who need to take NSAIDs long-term should talk to their doctor about monitoring for potential side effects and adjusting the dosage or switching to a different medication if necessary.

In conclusion, while Advil and aspirin can be effective for short-term pain relief, long-term use can have potential risks and side effects. It is important to talk to a healthcare provider about alternative treatments and monitoring for potential side effects if long-term NSAID use is necessary.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.medicalnewstoday.com/articles/322793
[3] https://www.healthline.com/health/pain-relief/aspirin-ibuprofen