Ibuprofen damages what organ?

Which organ does ibuprofen most commonly affect?

Ibuprofen most commonly damages the stomach (and intestines) by irritating the gastrointestinal lining. In some people it can cause ulcers and gastrointestinal bleeding. [1]

What other organs can ibuprofen harm?

It can also affect the kidneys, especially with higher doses, long-term use, dehydration, or in people with kidney disease. Ibuprofen can reduce blood flow to the kidneys and worsen kidney function. [1]

What about the liver?

Ibuprofen is less commonly associated with liver injury than with stomach and kidney problems, but liver injury can occur in rare cases. [1]

When is the risk highest?

The risk of organ injury rises with:
- Higher doses or combining with other NSAIDs
- Alcohol use
- Age (older adults)
- Dehydration or existing kidney disease
- A history of ulcers or GI bleeding [1]

Sources:
[1] https://www.drugs.com/sfx/ibuprofen-side-effects.html