Lipitor, also known as atorvastatin, is a medication that is used to lower cholesterol levels in the body [1]. Probiotics are live microorganisms that can provide health benefits when consumed in adequate amounts. They are commonly used to improve digestive health and boost the immune system.

There is limited research on the interaction between Lipitor and probiotics. However, a study published in the Journal of Medicinal Food found that atorvastatin can have a negative impact on the gut microbiome, which is the collection of microorganisms that live in the digestive tract. The study showed that atorvastatin decreased the number of beneficial bacteria in the gut and increased the number of harmful bacteria [2].

Another study published on BioRxiv, a preprint server for biology research, found that atorvastatin can interfere with the growth of certain strains of lactobacilli, which are beneficial bacteria commonly found in probiotics. The study showed that atorvastatin inhibited the growth of lactobacilli by affecting their metabolism [3].

Based on these studies, it is possible that Lipitor can decrease the effectiveness of probiotics by negatively impacting the gut microbiome and inhibiting the growth of beneficial bacteria. However, more research is needed to fully understand the interaction between Lipitor and probiotics.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904929/
[3] https://www.biorxiv.org/content/10.1101/712083v1.full.pdf