Does co administration affect tigecycline's potency?

Why does tigecycline need careful administration?

Tigecycline reaches higher levels in tissues than in blood. It distributes widely into organs such as liver, bone, and легкие, but its blood concentration drops quickly. This distribution pattern requires clinicians to give it alone rather than combined with other drugs that may alter its tissue penetration.

Does co-administration affect tigecycline's potency?

Co-administration of tigecycline with other drugs can affect its potency. Studies show that when tigecycline is given together with rifampin, its area under the curve drops 20–25 %. This is because rifampin speeds up the elimination of tigecycline. When it is combined with cyclosporine, cyclosporine slows down its elimination and raises its blood levels. When it is combined with warfarin, its blood levels may also verändern. When it is combined with oral contraceptives, the contraceptive effect may be reduced.

What happens if other drugs interfere with the distribution of tigecycline?

If other drugs interfere with the distribution of tigecycline into tissues, its effectiveness against bacteria in deep-seated infections like osteomyelitis or pneumonia can be reduced. For example, drugs that competes for binding to the 30S ribosomal subunit can occupy the target site and lower the bacteriostatic effect of tigecycline.

How long does the effect of co-administration remain?

The effect of co-administration remains until the drug is cleared from the system. The half-life of tigecycline is about 27 hours in healthy volunteers, so the influence of interfering drugs can persist for several days after the co- administered drug is 0.