Lacosamide is a medication used to treat partial-onset seizures in patients with epilepsy [2]. According to the FDA label for lacosamide, it is known to have potential interactions with other cardiovascular medications [3]. Specifically, lacosamide may interact with drugs that prolong the PR interval, such as beta-blockers, calcium channel blockers, and digoxin, as well as with drugs that are CYP3A4 inducers or inhibitors, such as rifampin, ketoconazole, and St. John's Wort [3]. Therefore, it is important for patients to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements, to avoid potential interactions [2]. Additionally, patients should not abruptly stop taking lacosamide without consulting their healthcare provider, as this can increase the risk of seizures [2]. It is also important to note that the information provided in the FDA label is not exhaustive, and patients should consult their healthcare provider or pharmacist for more information on potential drug interactions with lacosamide [3].

Sources:
[2] "Lacosamide." Epilepsy Foundation, 2021, https://www.epilepsy.com/medications/lacosamide.
[3] "Lacosamide." U.S. Food and Drug Administration, 2018, https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/022253s042lbl.pdf.