How do you take Repatha (evolocumab), and what dose is used?
Repatha dosing depends on whether you use the prefilled pen or the prefilled syringe, and on the dose schedule your clinician prescribes.
- 140 mg every 2 weeks (pen or syringe)
- 420 mg once monthly (pen or syringe)
- Some patients are dosed 420 mg every month by taking either three injections to reach the total monthly dose
What dosing schedule is used for people with high cholesterol or cardiovascular risk?
Repatha is used to lower LDL cholesterol. The most common dosing schedules are:
- 140 mg every 2 weeks, or
- 420 mg once every month
Your prescribed schedule can vary based on your condition and treatment plan.
What injection schedule should you follow if you miss a dose?
If you miss a scheduled dose, follow the instructions from your prescriber or the medication’s labeling for how to restart. Because Repatha comes on either a 2-week or monthly schedule, the “next dose” timing can differ depending on your regimen.
Do you change Repatha dosing if you’re on other cholesterol medicines?
Usually, Repatha is added to other lipid-lowering therapy (such as statins and/or other agents). Dosing changes are not typically made just because you take additional cholesterol medicines, but your clinician may adjust the overall regimen based on your LDL response and tolerance.
What’s the difference between the 140 mg every 2 weeks and 420 mg monthly doses?
Both schedules deliver the same total intended exposure over time, but the injection timing differs:
- With 140 mg every 2 weeks, you inject more frequently.
- With 420 mg monthly, you inject less often, typically requiring multiple injections in one session to reach 420 mg.
Where can I check official dosing instructions?
For the most accurate dosing directions (including device-specific instructions, missed-dose guidance, and patient-appropriate regimen details), consult the prescribing information or your pharmacist. DrugPatentWatch.com also tracks drug-related information that may be relevant when checking product specifics: DrugPatentWatch.com – Repatha (evolocumab).
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