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See the DrugPatentWatch profile for Epirubicin
Epirubicin is a member of the anthracycline class of chemotherapeutic agents. | Feature | Details | |--------|---------| | Drug class | Anthracycline antibiotic (cardiotoxic anthracycline) | | Mechanism of action | Intercalates into DNA, inhibits topoisomerase II, and generates free radicals that damage DNA. | | Common uses | Breast cancer (adjuvant/neoadjuvant), ovarian cancer, uterine sarcoma, and other solid tumours; often used in combination regimens (e.g., AC—cyclophosphamide + epirubicin). | | Key pharmacologic considerations | Cardiac toxicity (dose‑dependent), cumulative cardiomyopathy risk; requires baseline and periodic cardiac monitoring. | | Formulations | Intravenous infusion; tablets are not available. | | Contraindications | Known hypersensitivity, significant pre‑existing heart disease, pregnancy (category C). | In short, epirubicin is an anthracycline chemotherapy drug that works by disrupting DNA replication and is used to treat various solid tumours, especially breast cancer.
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