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What changes in nivolumab dosing occur with weight? Nivolumab dosing is calculated on a patient’s body weight. The standard dose is 3 mg per kilogram of body weight, given every two weeks. When patients gain or lose weight significantly, clinics recalculate the dose to keep exposure consistent. Clinics track weight at each visit and adjust accordingly. How does obesity affect nivolumab dosing? Obese patients need higher absolute doses because the calculation uses current body weight. Some centers explore fixed dosing or capped dosing for patients over 100 kg or 120 kg to avoid very large injections.
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