What's the limit for daily 325mg aspirin doses?

For adults taking aspirin (pain/fever relief) in 325 mg tablets, the typical maximum daily dose is 4,000 mg per 24 hours. That equates to up to 12 tablets of 325 mg per day (12 × 325 mg = 3,900 mg). You’d space them in divided doses (for example every 4–6 hours as needed) but should not exceed 4 g in a single day.

Important cautions:
- If you’re using aspirin for heart protection, you’d usually be on a much lower dose (often 81 mg) and not 325 mg.
- Do not give aspirin to children or teenagers with viral infections due to the risk of Reye’s syndrome.
- Avoid in people with ulcers, active GI bleeding, kidney disease, bleeding disorders, or those taking anticoagulants or other NSAIDs without a clinician’s guidance.
- If you have liver/kidney problems, are pregnant, or drink alcohol regularly, check with a healthcare professional before taking daily high-dose aspirin.

If you had a specific use in mind (pain, fever, or cardiovascular prevention) or want tips on minimizing GI side effects, tell me a bit more and I’ll tailor the guidance.