Does Jardiance Cause Constipation?
Jardiance (empagliflozin), an SGLT2 inhibitor for type 2 diabetes, does not list constipation as a common or reported side effect in clinical data or prescribing information. Common gastrointestinal issues with Jardiance include nausea or urinary tract infections, but constipation is absent from major trials like EMPA-REG OUTCOME, where GI adverse events were low overall.[1][2]
What Side Effects Does Jardiance Actually Cause?
Frequent side effects (>5% of patients) are urinary tract infections (7-9%), yeast infections (5-6% in women), and increased urination. Serious risks include dehydration, ketoacidosis, and genital infections. GI effects are mild and rare, typically limited to upper digestive upset rather than bowel changes like constipation.[1][3]
Why Might Someone Experience Constipation on Jardiance?
No direct causal link exists, but indirect factors could contribute:
- Dehydration from its diuretic effect (pulls water into urine) may harden stools if fluid intake is low.
- Dietary shifts for diabetes management or concurrent meds (e.g., metformin, which can cause diarrhea but sometimes alternates with constipation).
Patient forums report isolated constipation claims, often tied to these factors rather than the drug itself.[4]
How Does Jardiance Compare to Other Diabetes Drugs for Gut Issues?
| Drug | Constipation Risk | Common GI Effects |
|------|-------------------|-------------------|
| Jardiance (SGLT2) | None reported | Nausea (2-3%) |
| Metformin (biguanide) | Rare | Diarrhea (20-30%), nausea |
| Ozempic (GLP-1) | Low | Nausea, vomiting, diarrhea |
| Trulicity (GLP-1) | Low | Similar to Ozempic |
SGLT2s like Jardiance have the cleanest GI profile among oral diabetes meds.[2][5]
What Should You Do If Constipation Happens?
Increase water intake (aim for 8-10 glasses daily), add fiber-rich foods, and use over-the-counter remedies like stool softeners. Consult a doctor to rule out dehydration or interactions—don't stop Jardiance without advice, as it reduces heart and kidney risks.[1][3]
When to See a Doctor
Seek care if constipation lasts >3 days, includes blood, severe pain, or weight loss, as it could signal unrelated issues like low potassium from Jardiance's effects.
Sources
[1]: Jardiance Prescribing Information (FDA)
[2]: EMPA-REG OUTCOME Trial (NEJM)
[3]: Drugs.com - Jardiance Side Effects
[4]: WebMD Patient Reviews
[5]: Mayo Clinic Diabetes Meds Comparison