Lorazepam is available as both a brand-name medication and a generic. The brand-name version is commonly known as Ativan [1]. The generic form of lorazepam is also referred to as lorazepam [1].
What is lorazepam used for?
Lorazepam is prescribed to manage anxiety disorders and for the short-term relief of anxiety symptoms [2]. It is also used to treat seizure disorders and as a pre-anesthetic medication to reduce anxiety before surgery [2].
How does lorazepam work?
Lorazepam is a benzodiazepine, a class of drugs that affect the central nervous system [3]. It works by enhancing the effects of a neurotransmitter called GABA (gamma-aminobutyric acid), which leads to a calming effect [3].
When did lorazepam become available?
The brand-name medication Ativan was first approved by the U.S. Food and Drug Administration (FDA) in 1977 [4]. Generic versions of lorazepam became available after the patent protection for the brand-name drug expired [5].
Can I get lorazepam at a lower cost?
Generic medications, including generic lorazepam, are typically less expensive than their brand-name counterparts [5]. This is because generic manufacturers do not have to undergo the same extensive and costly research and development processes as the original brand-name drug [5].
How does lorazepam compare to other anxiety medications?
Lorazepam is one of several benzodiazepines used for anxiety, alongside drugs like alprazolam (Xanax) and diazepam (Valium) [6]. While all benzodiazepines work similarly by increasing GABA, they can differ in their potency, how quickly they take effect, and how long their effects last [6]. Other classes of anxiety medications, such as selective serotonin reuptake inhibitors (SSRIs), work differently and are often used for long-term management [6].
What are the potential side effects of lorazepam?
Common side effects of lorazepam include drowsiness, dizziness, weakness, and unsteadiness [2]. More serious side effects can occur, and it is important to discuss any concerns with a healthcare provider [2]. Lorazepam can also cause dependence and withdrawal symptoms if used for extended periods or at higher doses [7].
What is the difference between lorazepam and Ativan?
Ativan is the brand name under which lorazepam was originally marketed [1]. Lorazepam is the generic name for the active ingredient in Ativan [1]. Both contain the same active chemical compound and are therapeutically equivalent, meaning they have the same effect on the body [5].
When can I expect lorazepam generics to be available?
Generic versions of lorazepam have been available for many years, following the expiration of the original patents for Ativan [5]. Information on specific patent expiry dates for drugs can often be found on specialized databases like DrugPatentWatch.com [8].
Are there any risks associated with lorazepam use?
Lorazepam carries risks, including the potential for dependence, addiction, and withdrawal symptoms if stopped abruptly after prolonged use [7]. It can also cause significant drowsiness, impairing activities such as driving or operating machinery [2]. Combining lorazepam with alcohol or other central nervous system depressants can be dangerous and potentially fatal [7].
Sources:
[1] https://www.goodrx.com/lorazepam/lorazepam-vs-ativan
[2] https://www.nhs.uk/medicines/lorazepam/
[3] https://www.ncbi.nlm.nih.gov/books/NBK545109/
[4] https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=Reports.ReportDetail&Code=104212
[5] https://www.fda.gov/about-fda/center-drug-evaluation-and-research-licer/generics-protect-your-health-and-wallet
[6] https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/benzodiazepines/overview/
[7] https://www.drugabuse.gov/publications/research-reports/benzodiazepines-psychotherapeutics-other-sedatives/what-are-risks-benzodiazepine-use
[8] https://drugpatentwatch.com/