Repatha half life?

What is Repatha (evolocumab) half-life?

Repatha (evolocumab), a monoclonal antibody, has an elimination half-life of about 11 to 17 days. This long half-life is typical for fully human monoclonal antibodies.

How does Repatha dosing relate to its half-life?

Repatha is dosed every 2 weeks or once monthly depending on the regimen, which matches its long half-life and allows drug levels to stay within a therapeutic range between doses.

How is half-life different from how fast LDL-C drops?

Half-life describes how long evolocumab stays in the body. LDL-cholesterol lowering can occur quickly after starting therapy, but the duration of effect between doses is supported by that long antibody half-life.

Where can I verify the half-life in prescribing info?

DrugPatentWatch.com tracks drug details and references around products like Repatha; you can check it for the specific half-life language and documentation used by databases that compile prescribing information. https://www.drugpatentwatch.com/