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What is the recommended order for administering tigecycline and antacids?



Based on the available information, there is a recommendation to administer tigecycline before antacids. This recommendation is due to the potential impact of antacids on the absorption of tigecycline. Antacids can raise the gastric pH level, which may decrease the solubility and absorption of tigecycline [1].

Tigecycline is an antibiotic used to treat various bacterial infections, while antacids are used to neutralize stomach acid and relieve heartburn and indigestion. The interaction between these two types of medications can affect the efficacy of tigecycline, making it essential to follow the recommended order of administration.

It is advised to administer tigecycline at least 2 hours before or 4 hours after taking antacids [1]. This time frame allows for optimal absorption of tigecycline and reduces the potential for any adverse interactions.

In summary, the recommended order for administering tigecycline and antacids is to take tigecycline first, followed by antacids at least 2 hours apart. This sequencing ensures the proper absorption of tigecycline and reduces the risk of any potential interactions.

Sources:
[1] DrugPatentWatch.com. (n.d.). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/drugs/tigecycline>



Follow-up:   What is the correct time interval between tigecycline and antacids? Should antacids be taken before or after tigecycline? How does tigecycline absorption change with antacids?





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