What is the recommended dosage of stiripentol for patients?

Recommended Dosage for Stiripentol in Dravet Syndrome

Stiripentol (Diacomit) is approved for use with clobazam and valproate in patients aged 2 years and older with Dravet syndrome whose seizures are not adequately controlled with these drugs alone.1

Patients weighing 30 kg or more
- 50 mg/kg/day, given orally in 2 or 3 divided doses.

Patients weighing less than 30 kg
- 50 mg/kg/day, given orally in 2 or 3 divided doses.1

How to Administer Stiripentol

Take with food to improve absorption and reduce side effects like nausea. Powder form must be mixed with water and taken immediately; capsules can be opened and mixed with applesauce if swallowing is difficult.1

Dosage Adjustments

• Start at the full recommended dose; no titration needed.
  
• Reduce clobazam dose by half when adding stiripentol due to CYP2C19 inhibition, which increases clobazam levels.
  
• Adjust based on tolerability or weight changes; maximum daily dose is 3,000 mg.
  
• No specific adjustments for mild-to-moderate hepatic impairment; avoid in severe cases.1
  
  

What If a Dose Is Missed

Take as soon as remembered unless close to the next dose. Do not double up.1

Use in Children Under 2 or Other Conditions

Not approved or recommended for children under 2 years. No approvals for other epilepsy types outside Dravet syndrome with the specified regimen.1

Common Dosage-Related Side Effects

Higher doses increase risks of sedation, decreased appetite, and weight loss. Monitor weight and consider dose reduction if needed.1